Apomorphine (Apo-go injections)

  Britannia Pharmaceuticals Ltd (a subsidiary of STADA Arzneimittel AG since 2007) manufactures Apomorphine (Apo-go injections), with historical involvement from Bertek Pharmaceuticals (a Mylan subsidiary) for early launches like the UK rollout in 2002; other partners include US WorldMeds for Apokyn in the US.pubmed.ncbi.nlm.nih+3

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Apomorphine has been used since the 1860s for various indications, but modern Parkinson's subcutaneous use (approved ~2000s) initially noted from trials: nausea/vomiting (most common, dose-related), injection site reactions (hardening, nodules), dizziness, somnolence, hypotension, yawning, dyskinesia, and hallucinations.medicines+1

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Updates added severe allergic reactions (due to sodium metabisulfite), eosinophilic pneumonia, impulse control disorders (gambling, hypersexuality), dopamine dysregulation syndrome (addictive overuse), sudden sleep onset, aggression, and neuroleptic malignant syndrome-like withdrawal.adisinsight.springer+2

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Current SmPCs emphasize dyspnea, confusion, pallidal syndrome, hemolytic anemia, prolonged QT interval, and refined risks like fibrosis or cardiovascular events from long-term surveillance.adisinsight.springer+1

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1. https://pubmed.ncbi.nlm.nih.gov/15230626/
2. https://www.stada.com/blog/posts/2018/june/stada-recovers-top-selling-product-and-will-distribute-the-parkinsons-medication-in-germany-and-scandinavia-in-the-future
3. https://adisinsight.springer.com/drugs/800020307
4. https://firstwordpharma.com/story/4632337
5. https://www.pmcpa.org.uk/media/zuvmracs/3885-case-report-4-august-25.pdf
6. https://www.sciencedirect.com/science/article/pii/S1353802025006133
7. https://www.medicines.org.uk/emc/product/2232/smpc
8. https://www.britannia-pharm.co.uk/about/britannias-story