Ropinirole (Requip, Adartrel, Repinex)

 Ropinirole (Requip, Adartrel) is primarily manufactured by GlaxoSmithKline (GSK), with generics now produced by various companies including Teva, Mylan, and Accord.singlecare+1

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Initial approvals for Parkinson's disease in 1997 (US) and restless legs syndrome later highlighted common effects from trials: nausea, dizziness, somnolence, dyskinesia, syncope, asthenia, viral infection, leg edema, vomiting, dyspepsia, and orthostatic hypotension.medcentral+2

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Post-approval surveillance added sudden sleep onset, hallucinations, confusion, sweating, headache, falls, back pain, fainting, upper respiratory infection, heartburn, stomach pain, joint pain, tremor, visual impairment, high blood pressure, constipation, anxiety, dry mouth, pain, diarrhea, and memory loss.mayoclinic+2

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Current labels emphasize impulse control disorders (e.g., gambling, compulsive behaviors), worsening RLS (augmentation), withdrawal syndrome resembling neuroleptic malignant syndrome (fever, muscle stiffness, apathy, depression), atrial fibrillation, slow heartbeat, lung/heart complications, peripheral edema (up to 1/3 on extended-release), anterocollis, and overdose risks like agitation, chest pain, arrhythmias.ncbi.nlm.nih+2

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1. https://www.singlecare.com/blog/ropinirole-side-effects/
2. https://www.medcentral.com/drugs/monograph/4468-398013/ropinirole-oral
3. https://www.ncbi.nlm.nih.gov/books/NBK554532/
4. https://www.healthline.com/health/drugs/ropinirole-oral-tablet
5. https://www.mayoclinic.org/drugs-supplements/ropinirole-oral-route/description/drg-20066810
6. https://www.nhs.uk/medicines/ropinirole/side-effects-of-ropinirole/
7. https://www.webmd.com/drugs/2/drug-4468-4041/ropinirole-oral/ropinirole-oral/details
8. https://my.clevelandclinic.org/health/drugs/20503-ropinirole-oral-tablets
9. https://medlineplus.gov/druginfo/meds/a698013.html
10. https://www.goodrx.com/ropinirole/what-is